Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells

摘要

Genes that promote hematopoietic stem cell (HSC) quiescence play important roles in the maintenance of their function. Here we show a novel role for the evolutionarily conserved flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase, growth factor erv1-like (Gfer) in the restriction of HSC proliferation through its inhibition of Jab1-mediated turnover of p27kip1.